What are natural antisense transcripts good for?
نویسندگان
چکیده
NATs (natural antisense transcripts) are important regulators of eukaryotic gene expression. Interference between the expression of protein-coding sense transcripts and the corresponding NAT is well documented. In the present review, we focus on an additional, higher-order role of NATs that is currently emerging. The recent discovery of endogenous siRNAs (short interfering RNAs), as well as NAT-induced transcriptional gene silencing, are key to the proposed novel function of NATs.
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عنوان ژورنال:
- Biochemical Society transactions
دوره 38 4 شماره
صفحات -
تاریخ انتشار 2010